Position

Maître de Conférences  (MCU)

Coordonnées

Laboratoire AME2P
3 rue de la Chebarde
Campus Universitaire des Cézeaux
63170 Aubière CEDEX
Laurie.Isacco@uca.fr 

Programme de recherche


Programme A: Identification des adaptations physiologiques et énergétiques aux déficits énergétiques.  

Parcours


Master 2 APAS recherche - UFR STAPS Clermont-Ferrand
Doctorat - Laboratoire AME2P, Clermont-Ferrand
Post-doctorat - Université de Fribourg, Suisse
MCU - UFR STAPS de Besançon, Université Bourgogne Franche-Comté
Ingénieur de recherche - Laboratoire AME2P, Clermont-Ferrand

Thématique de recherche


Mes thématiques de recherche s'articulent autour de l'étude de la composition corporelle, du métabolisme énergétique et des réponses endocriniennes en lien avec l'exercice physique de différentes intensités, que ce soit dans un objectif de prévention primaire ou tertiaire de santé ou dans l'optimisation du suivi du sportif. Un intérêt tout particulier est porté à la population féminine.

Mots clés


Métabolisme énergétique, composition corporelle, hormones, niveau d'activité physique, femme

Responsabilités


2023 - … Responsable parcours Licence Activité Physique Adaptée Santé, UFR STAPS, Clermont Auvergne Université, Clermont-Ferrand

Publications

Publications 2026

1: Pélissier L, Ramos I, Drapeau V, Finlayson G, Pereira B, Beraud D, Duclos M, Boirie Y, Isacco L, Thivel D. Normal-weight individuals experience an increased drive to eat and greater meal-satiety response in response to weight-loss: results from the NUTRILEX project. Physiol Behav. 2026

2: Marcantei C, Metz L, Ramos I, Pereira B, Dutheil F, De Saint Vincent S, Duclos M, Isacco L. No effect of menopausal status on energy cost and substrate oxidation during walking in women with similar body composition and movement behaviors. Physiol Behav. 2026 

3: Thivel D, Beraud D, Siroux J, Moore H, Marcantei C, Tarrit B, Finlayson G, Mathieu ME, Miyashita M, Julian V, Duclos M, Boirie Y, Pereira B, Isacco L. Acute Exercise Induced Energy Expenditure and Substrate Oxidation Rates Might Not Be Associated With Subsequent Appetitive Responses in Adolescents Living With Obesity. Pediatr Obes. 2026 

4: Ghamdi Z, Moore H, Siroux J, Beraud D, Alkahtani S, Alghannam AF, Pereira B, Masurier J, Finlayson G, Julian V, Isacco L, Thivel D. The Appetitive Responses to a Meal Are Not Affected by Its Carbohydrate Content in Adolescents With Obesity: A Pilot Study. Pediatr Obes. 2026


Publications 2025

1: Thivel D, Doucet É, Lazzer S, Montaurier C, Pereira B, Bosy-Westphal A, Muller MJ, Boirie Y, Isacco L. Adaptive thermogenesis in response to weight loss and weight regain: first evidence in adolescents with severe obesity. Br J Nutr. 2025

2: Bagot S, Pereira B, Fournier E, Gryson C, Chanséaume Bussière E, Dutheil F, DE Saint Vincent S, Miles-Chan JL, Hackney AC, Thivel D, Duclos M, Isacco L. Metabolic responses to energetic stimuli in female athletes using or not hormonal contraceptives during a high training load period. J Sports Med Phys Fitness. 2025 N

3: Bailly M, Isacco L, Dutheil F, Courteix D, Lesourd B, Chapier R, Obert P, Walther G, Bagheri R, Vinet A, Metz L, Verney J, Ennequin G, Drapeau V, Pereira B, Thivel D, Tremblay A. Initial and evolutionary profile of adverse responders to an intensive weight loss intervention: the RESOLVE Study. J Sports Med Phys Fitness. 2025 

4: Bailly M, Thivel D, Isacco L, Verney J. Unique Energy Profile Associated with Persistent Thin Phenotype. Annu Rev Nutr. 2025 

5: Isacco L, Bailly M, Lambert C, Beraud D, Duclos M, Verney J, Boirie Y, Thivel D. Influence of body composition on energy metabolism in females with constitutional thinness. Eur J Clin Nutr. 2025 

6: Thivel D, Hopkins M, Lazzer S, Montaurier C, Moore H, Pereira B, Blundell JE, Isacco L, Boirie Y. Examining the roles of body composition, energy expenditure and substrate metabolism in the control of daily energy intake in adolescents with obesity. Int J Obes (Lond). 2025 

7: Bagot S, Miles-Chan J, Hackney AC, Duclos M, Isacco L. Female Exercise Metabolism: Quality Assessment of Existing Knowledge Base and Key Challenges in Study Design. Int J Sport Nutr Exerc Metab. 2025 

8: Pélissier L, Ramos I, Pereira B, Boirie Y, Duclos M, Thivel D, Isacco L. Initial adiposity is associated with body composition changes in response to diet-induced weight loss in normal-weight healthy individuals: The first results of the NUTRILEX study. Physiol Behav. 2025 

9: Bagot S, Ramos I, Miles-Chan J, Dulloo A, Hackney A, Boirie Y, Duclos M, Thivel D, Isacco L. The type of sport, but not sex, impacts body composition and metabolic response to a complete weight loss-weight regain episode in weight cycling athletes: results from the WAVE study. Appl Physiol Nutr Metab. 2025 

10: Bagot S, Ramos I, Hackney AC, Finlayson G, Fournier E, Boirie Y, Duclos M, Isacco L, Thivel D. Appetite-Control and Eating-Behavior Traits Might Not Be Impacted by a Single Weight-Cycling Episode in Weight-Cycling Athletes: Results of the Wave Study. Int J Sports Physiol Perform. 2025 

11: Metz L, Guirado T, Moore H, Brun C, Pereira B, Thivel D, Duclos M, Isacco L. Standing or Very Low-Intensity Cycling as Sedentary Breaks: Does Physical Activity Level Matter? J Phys Act Health. 2025

12: Thivel D, Ennequin G, Siroux J, Couret A, Beraud D, Pereira B, Duclos M, Lazzer S, Boirie Y, Isacco L. Acute simulated weight gain might not increase the energy cost of walking in adolescents with obesity. Pediatr Obes. 2025 

Publications 2024

1. Thivel D, Ennequin G, Lambert C, Siroux J, Ratel S, Boscaro A, Pelissier L, Julian V, Cardenoux C, Duclos M, Lazzer S, Pereira B, Boirie Y, Isacco L. Improved walking energy efficiency might persist in presence of simulated full weight regain after multidisciplinary weight loss in adolescents with obesity: the POWELL study. Int J Obes (Lond). 2024 

2. Bagot S, Pélissier L, Pereira B, Chanséaume Bussiere E, Duclos M, Dulloo A, Miles-Chan J, Charlot K, Boirie Y, Thivel D, Isacco L. Weight regain, body composition, and metabolic responses to weight loss in weight cycling athletes: A systematic review and meta-analyses. Obes Rev. 2024 

3. Pélissier L, Lambert C, Moore H, Beraud D, Pereira B, Boirie Y, Duclos M, Thivel D, Isacco L. Postprandial energy metabolism is modulated in response to a low-intensity walking exercise in fasted healthy individuals. Nutr Res. 2024 

4. Bagot S, Pereira B, Lambert C, Pelissier L, Chanseaume E, Duclos M, Hackney AC, Elliott-Sale KJ, Thivel D, Isacco L. A reproducible, self-reported, field-based tool for monitoring ovarian hormone status and body weight variations in female athletes: the Answ'Her questionnaire. J Sports Med Phys Fitness. 2024 

5. Bailly M, Beraud D, Lambert C, Garnier YM, Pereira B, Duclos M, Boirie Y, Isacco L, Thivel D, Verney J. Constitutional thinness might be characterized by physiologically adapted and not impaired muscle function and architecture: new results from the NUTRILEAN study. Eur J Appl Physiol. 2024 

6. Pélissier L, Lambert C, Stensel DJ, Beraud D, Finlayson G, Pereira B, Boirie Y, Duclos M, Isacco L, Thivel D. Individual variability and consistency of post-exercise energy and macronutrient intake, appetite sensations, and food reward in healthy adults. Appetite. 2024 

7. Pélissier L, Lambert C, Stensel DJ, Beraud D, Finlayson G, Pereira B, Boirie Y, Duclos M, Isacco L, Thivel D. Individual variability and consistency of post-exercise energy and macronutrient intake, appetite sensations, and food reward in healthy adults. Appetite. 2024 

8. Allali B, Pereira B, Fillon A, Pouele L, Masurier J, Cardenoux C, Isacco L, Boirie Y, Duclos M, Thivel D, Julian V. The effectiveness of multidisciplinary weight loss interventions is associated with initial cardiorespiratory fitness in adolescents with obesity. Pediatr Obes. 2024 

9. Pélissier L, Beraud D, Pereira B, Couret A, Isacco L, Thivel D. Are anti-gravity treadmills reliable to explore exercise energy metabolism at low degrees of alleviation in normal-weight male individuals? Technol Health Care. 2024

10. Siroux J, Moore H, Isacco L, Couvert A, Pereira B, Julian V, Duclos M, Miyashita M, Finlayson G, Boirie Y, Thivel D. Acute exercise might not affect subsequent appetite responses to a fixed meal in adolescents with obesity: The SMASH exploratory study. Appetite. 2024 

11. Bagot S, Pereira B, Miles-Chan J, Gryson C, Chanséaume Bussière E, Duclos M, Thivel D, Isacco L. The habitual degree of weight loss might be associated with specific fat and protein intakes during a period of weight maintenance in athletes used to weight variations: preliminary results from the WAVE study. Nutr Res. 2024 

12. Thivel D, Ennequin G, Siroux J, Couret A, Beraud D, Pereira B, Duclos M, Lazzer S, Boirie Y, Isacco L. Acute simulated weight gain might not increase the energy cost of walking in adolescents with obesity. Pediatr Obes. 2024 

Publications 2023

1: Moore H, Siroux J, Pereira B, Miguet M, Fillon A, Dionnet C, Julian V, Duclos M, Boirie Y, Finlayson G, Isacco L, Thivel D. The energy content of meals with a similar macronutrient distribution may have a greater impact on appetite sensations than food preferences in adolescents with obesity: A secondary analysis. Appetite. 2023 

2: Siroux J, Pereira B, Fillon A, Moore H, Dionnet C, Julian V, Finlayson GS, Duclos M, Boirie Y, Isacco L, Thivel D. Higher energy flux may improve short-term appetite control in adolescents with obesity: the NEXT study. Br J Nutr. 2024

3: Fournier E, Łuszczki E, Isacco L, Chanséaume-Bussiere E, Gryson C, Chambrier C, Drapeau V, Chaput JP, Thivel D. Toward an Integrated Consideration of 24 h Movement Guidelines and Nutritional Recommendations. Nutrients. 2023 

4: Isacco L, Lambert C, Siroux J, Boscaro A, Cardenoux C, Julian V, Duclos M, Boirie Y, Pereira B, Ennequin G, Thivel D. Weight loss does not affect the sit-to-stand metabolic cost in adolescents with obesity. Eur J Appl Physiol. 2023 

5: Pélissier L, Bagot S, Miles-Chan JL, Pereira B, Boirie Y, Duclos M, Dulloo A, Isacco L, Thivel D. Is dieting a risk for higher weight gain in normal-weight individual? A systematic review and meta-analysis. Br J Nutr. 2023 

6: Pélissier L, Ennequin G, Bagot S, Pereira B, Lachèze T, Duclos M, Thivel D, Miles-Chan J, Isacco L. Lightest weight-class athletes are at higher risk of weight regain: results from the French-Rapid Weight Loss Questionnaire. Phys Sportsmed. 2023 

Publications 2022


1: Fillon A, Pélissier L, Beaulieu K, Charlot K, Siroux J, Bagot S, Bailly M, Boscaro A, Finlayson G, Boirie Y, Duclos M, Isacco L, Pereira B, Julian V, Thivel D. Dietary- but not exercise-induced acute iso-energetic deficit result in short-term appetitive compensatory responses in adolescents with obesity. Appetite. 2022 

2: Ennequin G, Thivel D, Mourot L, Isacco L. Physically active men present a healthier cardiometabolic profile in response to a balanced meal compared to inactive men. Eur J Appl Physiol. 2023

3: Isacco L, Lambert C, Fearnbach N, Fillon A, Masurier J, Lowe M, Benson L, Duclos M, Pereira B, Boirie Y, Thivel D. Patterns of body weight change affect weight loss during a multidisciplinary intervention in adolescents with obesity. Obes Res Clin Pract. 2022

4: Isacco L, Lazzer S, Pereira B, Fearnbach N, Montaurier C, Vermorel M, Rannou F, Boirie Y, Thivel D. Association of protein-energy partitioning with body weight and body composition changes in adolescents with severe obesity. Int J Obes (Lond). 2022 

5: Guirado T, Bourdier P, Pereira B, Le Roux E, Bergouignan A, Birat A, Isacco L, Thivel D, Duclos M, Metz L. Metabolic profile in women differs between high versus low energy spenders during a low intensity exercise on a cycle-desk. Sci Rep. 2022 

6: Isacco L, Gimenez P, Ennequin G, Mourot L, Grosprêtre S. Cardiometabolic and neuromuscular analyses of the sit-to-stand transition to question its role in reducing sedentary patterns. Eur J Appl Physiol. 2022 

7: Pélissier L, Ennequin G, Bagot S, Pereira B, Lachèze T, Duclos M, Thivel D, Miles-Chan J, Isacco L. Lightest weight-class athletes are at higher risk of weight regain: results from the French-Rapid Weight Loss Questionnaire. Phys Sportsmed. 2023 

8: Pélissier L, Julian V, Beaulieu K, Siroux J, Boscaro A, Fillon A, Finlayson G, Duclos M, Boirie Y, Pereira B, Isacco L, Thivel D. Effect of acute dietary-versus combined dietary and exercise-induced energy deficits on subsequent energy intake, appetite and food reward in adolescents with obesity. Physiol Behav. 2022

9: Metz L, Isacco L, Redman LM. Effect of oral contraceptives on energy balance in women: A review of current knowledge and potential cellular mechanisms. Metabolism. 2022 

10: Boisseau N, Isacco L. Substrate metabolism during exercise: Sexual dimorphism and women's specificities. Eur J Sport Sci. 2022 

Publications 2021

Grosprêtre S, Marusic U, Gimenez P, Ennequin G, Mourot L, Isacco L. Stand up to excite the spine: neuromuscular, autonomic, and cardiometabolic responses during motor imagery in standing versus sitting posture (2021). Frontiers in physiology.12: 762452.

D’Alleva M, Gonnelli F, Vaccari F, Boirie Y, Montaurier C, Thivel D, Isacco L, Vermorel M, Lazzer S. Energy cost of walking and body composition changes during a 9-month multidisciplinary weight reduction program and 4-month follow-up in adolescents with obesity (2021). Appl Physiol Nutr Metab. 

Boisseau N, Isacco L. Substrate metabolism during exercise: sexual dimorphism and women’s specificities (2021). Eur J Sport Sci. In press.

Isacco L, Ennequin G, Boisseau N. Influence of the different hormonal status changes during their life on fat mass localisation in women: a narrative review (2021). Arch Physiol Biochem. In press.

Calonne J, Fares EJ, Montani JP, Schutz Y, Dulloo A, Isacco L. Dynamics of fat oxidation from sitting at rest to light exercise in inactive young humans (2021). Metabolites. 11(6): 334.

Charles M, Thivel D, Verney J, Isacco L, Husu P, Vähä-ypyä H, Vasankari T, Tardieu M, Fillon A, Genin P, Larras B, Chabanas B, pereira B, Duclos M. Reliability and validity of the ONAPS physical activity questionnaire in assessing physical activity and sedentary behavior in French adults (2021). Int J Environ Res Public Health. 18(11): 5643.

Grosprêtre S, Ennequin G, Peseux S, Isacco L. Feasability and acceptability of “active” classroom workstations among French university students and lecturers: a pilot study. (2021). BMC Public Health. 21(1): 1001.

Metz L, Isacco L, Miguet M, Genin P, Thivel D, Duclos M. Comparing the Effects of Immersed Versus Land-Based High-Intensity Interval Cycling on Energy Intake, Appetite Sensations and Perceived Exertion Among Healthy Men (2021). Percept Mot Skills. 128(4): 1569-1585.

Metz L, Isacco L, Fearnbach N, Pereira B, Thivel D, Duclos M. Energy Intake and Appetite Sensations Responses to Aquatic Cycling in Healthy Women: The WatHealth Study (2021).

Nutrients. 13(4): 1051.

Thivel D, Metz L, Julian V, Isacco L, Verney J, Ennequin G, Charlot K, Beaulieu K, Finlayson G, King JA. Diet- but not exercise-induced iso-energetic deficit induces compensatory appetitive responses (2021). Eur J Clin Nutr. 75(10): 1425-1432.

Metz L, Isacco L, Beaulieu K, Fearnbach SN, Pereira B, Thivel D, Duclos M. Cold-Water Effects on Energy Balance in Healthy Women During Aqua-Cycling (2021). Int J Sport Nutr Exerc Metab. 31(3):236-243.

Khammassi M, Isacco L, Pereira B, Damaso AR, Matlosz P, Maruszczak K, Weghuber D, Dutheil F, Duclos M, Boirie Y, Julian V, Thivel D. Cardiometabolic efficacy of multidisciplinary weight loss interventions is not altered in adolescents with obesity initially diagnosed or with a persistent metabolic syndrome (2021). Nutr Res. 86: 79-87.


Publications 2020

Miles-Chan JL, Isacco L. Weight cycling practices in sport: A risk factor for later obesity? (2020). Obes Rev. 22 Suppl 2: e13188.
Julian V, Isacco L, Khammassi M, Fillon A, Miguet M, Dutheil F, Courteix D, Zak M, Bicki J, Głuszek S, Duclos M, Boirie Y, Pereira B, Thivel D. Appetite Control Might not Be Improved after Weight Loss in Adolescents with Obesity, Despite Non-Persistent Metabolic Syndrome (2020). Nutrients. 12(12): 3885.
Isacco L, Ennequin G, Boisseau N. Effect of Fat Mass Localization on Fat Oxidation During Endurance Exercise in Women (2020). Front Physiol. 11: 585137.
Roche J, Corgosinho FC, Isacco L, Scheuermaier K, Pereira B, Gillet V, Moreira GA, Pradella-Hallinan M, Tufik S, de Mello MT, Mougin F, Dâmaso AR, Thivel D. A multidisciplinary weight loss intervention in obese adolescents with and without sleep-disordered breathing improves cardiometabolic health, whether SDB was normalized or not. Sleep Med. 75: 225-235.
Mourot L, Fornasiero A, Rakobowchuk M, Isacco L, Brighenti A, Stella F, Zignoli A, Pelligrini B, Tarperi C, Schena F (2020). Post-exercise hypotension and reduced cardiac baroreflex after half-marathon run: in men, but not in women. Int J Environ Res Public Health. 17(17): 6337
Roche J, Corgosinho FC, Damaso AR, Isacco L, Miguet M, Fillon A, Guyon A, Moreira G.A, Pradella-Hallinan M, Tufik S, de Mello MT, Gillet V, Pereira B, Duclos M, Boirie Y, Masurier J, Franco P, Thivel D, Mougin F (2020). Sleep-disordered breathing in adolescents with obesity: When does it start to affect cardiometabolic health? Nutrition, Metabolism & Cardiovascular Disease. 30(4): 683-693.
Roche J, Isacco L, Masurier J, Pereira B, Mougin F, Chaput JP, Thivel D (2020). Are obstructive sleep apnea and sleep improved in response to multidisciplinary weight loss interventions in adolescents with obesity? A systematic review and meta-analysis. Int J Obes. 44(4): 753-770.
Isacco L, Degoutte F, Ennequin G, Pereira B, Thivel D, Filaire E (2020). Rapid weight loss influences the physical, psychological and biological responses during a simulated competition in national judo athletes. Eur J Sport Sci. 20(5): 580-591.